The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 15, 2025
Filed:
Feb. 12, 2021
Applicant:
The Johns Hopkins University, Baltimore, MD (US);
Inventors:
William R. Bishai, Baltimore, MD (US);
Trinity J. Bivalacqua, Baltimore, MD (US);
Alok Singh, Baltimore, MD (US);
Monali Praharaj, Baltimore, MD (US);
Takahiro Yoshida, Baltimore, MD (US);
Assignee:
THE JOHNS HOPKINS UNVERSITY, Baltimore, MD (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/74 (2006.01); A61K 9/00 (2006.01); A61K 38/17 (2006.01); A61K 38/45 (2006.01); A61K 39/395 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); C07K 14/47 (2006.01); C12N 9/12 (2006.01);
U.S. Cl.
CPC ...
C12N 15/74 (2013.01); A61K 9/0019 (2013.01); A61K 38/1709 (2013.01); A61K 38/45 (2013.01); A61K 39/3955 (2013.01); A61P 35/00 (2018.01); C07K 14/4703 (2013.01); C07K 14/4705 (2013.01); C12N 9/1241 (2013.01); C12Y 207/07 (2013.01); A61K 48/00 (2013.01);
Abstract
Described are methods of suppressing the expression of myeloid-derived suppressor cells (MDSCs), M2 macrophages, and Treg cells in a tumor and inducing the expression of macrophages, dendritic cells (DCs), and T effector cells in a tumor in a subject. A pharmaceutical composition comprising a strain ofincluding an expression vector of the present invention is administered to a subject.