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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12359209 B1

PDFFull Text
Date of Patent:
Jul. 15, 2025

Filed:

Feb. 12, 2021

Recombinant therapeutic interventions for cancer

Applicant:

The Johns Hopkins University, Baltimore, MD (US);

Inventors:

William R. Bishai, Baltimore, MD (US);

Trinity J. Bivalacqua, Baltimore, MD (US);

Alok Singh, Baltimore, MD (US);

Monali Praharaj, Baltimore, MD (US);

Takahiro Yoshida, Baltimore, MD (US);

Assignee:

THE JOHNS HOPKINS UNVERSITY, Baltimore, MD (US);

Attorney:

DLA PIPER LLP (US)

Primary Examiner:

Jana A Hines

Assistant Examiner:

Khatol S Shahnan Shah

Int. Cl.
CPC ...
C12N 15/74 (2006.01); A61K 9/00 (2006.01); A61K 38/17 (2006.01); A61K 38/45 (2006.01); A61K 39/395 (2006.01); A61K 48/00 (2006.01); A61P 35/00 (2006.01); C07K 14/47 (2006.01); C12N 9/12 (2006.01);
U.S. Cl.
CPC ...
C12N 15/74 (2013.01); A61K 9/0019 (2013.01); A61K 38/1709 (2013.01); A61K 38/45 (2013.01); A61K 39/3955 (2013.01); A61P 35/00 (2018.01); C07K 14/4703 (2013.01); C07K 14/4705 (2013.01); C12N 9/1241 (2013.01); C12Y 207/07 (2013.01); A61K 48/00 (2013.01);
Abstract

Described are methods of suppressing the expression of myeloid-derived suppressor cells (MDSCs), M2 macrophages, and Treg cells in a tumor and inducing the expression of macrophages, dendritic cells (DCs), and T effector cells in a tumor in a subject. A pharmaceutical composition comprising a strain ofincluding an expression vector of the present invention is administered to a subject.

Find Patent Forward Citations

Bishai, William. (2025). Recombinant therapeutic interventions for cancer (U.S. Patent No. 12359209). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12359209

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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