The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 15, 2025
Filed:
Jan. 28, 2020
Applicant:
University of Rochester, Rochester, NY (US);
Inventor:
Rudi Fasan, Rochester, NY (US);
Assignee:
University of Rochester, Rochester, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/10 (2006.01); C07K 14/005 (2006.01); C07K 14/245 (2006.01); C07K 14/395 (2006.01); C12N 9/00 (2006.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1037 (2013.01); C07K 14/005 (2013.01); C07K 14/245 (2013.01); C07K 14/395 (2013.01); C12N 9/93 (2013.01); C12N 15/11 (2013.01); C07K 2319/40 (2013.01);
Abstract
Methods and compositions are provided for the display of genetically encoded macrocyclic peptides on a biological surface. Also provided are nucleic acid molecules, polypeptides, and methods for generating combinatorial libraries of macrocyclic peptides displayed on a biological surface. These methods can be used to produce and screen vast libraries of conformationally constrained peptides in a high-throughput manner, from which macrocyclic peptides with a desired property can be selected and identified.