The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 15, 2025
Filed:
May. 24, 2018
Applicant:
Thoeris Gmbh, Vienna, AT;
Inventor:
Tamara Nicolson, London, GB;
Assignee:
Thoeris GmbH, Vienna, AT;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/00 (2006.01); A61K 31/216 (2006.01); A61K 38/43 (2006.01); A61K 38/53 (2006.01); A61K 47/60 (2017.01); A61P 3/00 (2006.01); A61P 7/00 (2006.01); C07K 14/00 (2006.01); C07K 19/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/93 (2013.01); C12Y 603/01002 (2013.01); A61K 31/216 (2013.01); A61K 38/43 (2013.01); A61K 38/53 (2013.01); A61K 47/60 (2017.08); A61P 3/00 (2018.01); A61P 7/00 (2018.01); C07K 14/00 (2013.01); C07K 19/00 (2013.01);
Abstract
The present invention relates to the use of glutamine synthetase as a protein therapy (such as enzyme replacement protein therapy) for the treatment of hyperammonemia. In particular the invention relates to the systemic administration of glutamine synthetase. The glutamine synthetase may be provided in conjugated or fusion form, to increase its half-life in the circulation. Also provided is a pharmaceutical composition comprising glutamine synthetase. The invention also relates to the uses, methods and compositions involving a combination of the glutamine synthetase protein and an ammonia lowering agent, such as a nitrogen scavenger.