The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 15, 2025
Filed:
Nov. 30, 2023
Marshall University Research Corporation, Huntington, WV (US);
Hongwei D. Yu, Huntington, WV (US);
Meagan E. Valentine, Huntington, WV (US);
Richard M. Niles, Huntington, WV (US);
Thomas Ryan Withers, Huntington, WV (US);
Brandon D. Kirby, Huntington, WV (US);
Marshall University Research Corporation, Huntington, WV (US);
Abstract
Bacterial cultures are provided that comprise a modifiedbacterium missing or deficient in two or more virulence factors. The two or more virulence factors can be selected from exotoxin A, hemolytic phospholipase C, phenazine-specific methyltransferase, alpha-1,3-rhamnosyltransferase, and 3-phosphoshikimate 1-carboxyvinyltransferase. Certain of the modifiedbacteria are also missing or deficient in one or more alginate acetylation enzymes including the alginate O-acetyltransferases AlgI, AlgJ, AlgF, AlgX, and/or the C5-mannuronan epimerase AlgG. Methods of producing alginate are also provided along with compositions comprising alginate produced by the modifiedbacteria.