The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 15, 2025
Filed:
Dec. 28, 2018
Shanghai Cell Therapy Group Co., Ltd., Shanghai, CN;
Qijun Qian, Shanghai, CN;
Huajun Jin, Shanghai, CN;
Duqing Jiang, Shanghai, CN;
Zhou He, Shanghai, CN;
Shumei You, Shanghai, CN;
Xi Tang, Shanghai, CN;
Linfang Li, Shanghai, CN;
Chao Wang, Shanghai, CN;
Lianzhen Cui, Shanghai, CN;
SHANGHAI CELL THERAPY GROUP CO., LTD., Shanghai, CN;
Abstract
The invention relates to a T cell expressing an antibody or comprising the coding sequence of the antibody or an expression vector thereof; the antibody contains an optional signal peptide, an antigen binding sequence and a mutant type Fc segment, wherein the mutant type Fc segment is a Fc segment in which amino acid residues at the 17th site and the 79th site of the IgG4 Fc segment shown by SEQ ID NO: 25 are mutated into E and Q respectively. Preferably, the T cell is a CAR-T cell. The present invention further relates to a treatment application of the T cell in malignant tumors.