The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 15, 2025
Filed:
Mar. 10, 2020
Merck Sharp & Dohme Llc, Rahway, NJ (US);
Drake LaFace, Half Moon Bay, CA (US);
Juha Punnonen, Belmont, CA (US);
Edward Bowman, Bowman, CA (US);
David Bauche, San Mateo, CA (US);
Alissa Chackerian, Sunnyvale, CA (US);
Jeffery Grein, Sunnyvale, CA (US);
Smita Mauze, Belmont, CA (US);
Anandi Sawant, Sunnyvale, CA (US);
Lakshmanan Annamalai, Dublin, CA (US);
Merck Sharp & Dohme LLC, Rahway, NJ (US);
Abstract
Anti-cancer combination therapies comprising a CTLA-4 blocking agent and a PD-1 blocking agent are disclosed. In particular, combination therapies are disclosed wherein the CTLA-4 blocking agent is an effector-silent anti-CTLA-4 antibody or effector-silent anti-CTLA-4 antibody fragment and the PD-1 blocking agent is an anti-PD-1 or anti-PD-L1 antibody, or antibody fragment thereof.