The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 15, 2025
Filed:
Aug. 13, 2021
Marengo Therapeutics, Inc., Cambridge, MA (US);
Andreas Loew, Boston, MA (US);
Nidhi Malhotra, Boston, MA (US);
Madan Katragadda, Acton, MA (US);
Seng-Lai Tan, Sudbury, MA (US);
Jonathan Hsu, Waltham, MA (US);
Brian Edward Vash, Cambridge, MA (US);
Stephanie J. Maiocco, Arlington, MA (US);
Peter Marek, Hudson, MA (US);
Gurkan Guntas, Newton, MA (US);
Marengo Therapeutics, Inc., Cambridge, MA (US);
Abstract
Multifunctional molecules that include i) an antigen binding domain that binds to a T cell receptor beta chain constant domain 1 or T cell receptor beta chain constant domain 2; and one, two or all of: (ii) an immune cell engager (e.g., chosen from an NK cell engager, a T cell engager, a B cell engager, a dendritic cell engager, or a macrophage cell engager); (iii) a cytokine molecule or cytokine inhibitor molecule; (iv) a death receptor signal enhancer; and/or (v) a stromal modifying moiety are disclosed. Additionally disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.