The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 15, 2025

Filed:

May. 24, 2023
Applicant:

Ajou University Industry-academic Cooperation Foundation, Suwon, KR;

Inventors:

Yong Sung Kim, Suwon, KR;

Keunok Jung, Suwon, KR;

Ji Hee Ha, Daegu, KR;

Dong Ki Choi, Daejeon, KR;

Hye Ji Choi, Suwon, KR;

Ye Jin Kim, Busan, KR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/20 (2006.01); A61K 38/00 (2006.01); C07K 14/54 (2006.01); C07K 14/59 (2006.01);
U.S. Cl.
CPC ...
C07K 14/5434 (2013.01); A61K 38/208 (2013.01); C07K 14/54 (2013.01); C07K 14/59 (2013.01); A61K 38/00 (2013.01); C07K 2319/30 (2013.01);
Abstract

The present invention relates to a heterodimeric Fc-fused protein comprising a first Fc region and a second Fc region of an immunoglobulin Fc pair and a physiologically active protein composed of two or more different subunits, wherein one or more subunits of the physiologically active protein are linked separately to one or more ends of the N-terminus or C-terminus of the first Fc region and/or the second Fc region, and CH3 domains of the first Fc region and the second Fc region are mutated so as to promote the heterodimeric Fc formation. Moreover, the present invention relates to a pharmaceutical composition comprising the heterodimeric Fc-fused protein.


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