The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 15, 2025

Filed:

Jan. 21, 2021
Applicants:

United Therapeutics Corporation, Silver Spring, MD (US);

The United States of America As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);

Inventors:

David Meh, Columbia, MD (US);

Timothy Atolagbe, Elkridge, MD (US);

G. Mark Farquharson, Vienna, VA (US);

Samir Shaban, Frederick, MD (US);

Mary Koleck, Rockville, MD (US);

George Mitra, Potomac, MD (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 1/36 (2006.01); B01D 15/12 (2006.01); B01D 15/18 (2006.01); B01D 15/24 (2006.01); B01D 15/36 (2006.01); B01D 15/38 (2006.01); B01D 61/16 (2006.01); C07K 1/14 (2006.01); C07K 1/18 (2006.01); C07K 1/34 (2006.01); C07K 16/18 (2006.01); C07K 16/30 (2006.01);
U.S. Cl.
CPC ...
C07K 1/36 (2013.01); B01D 15/125 (2013.01); B01D 15/1871 (2013.01); B01D 15/24 (2013.01); B01D 15/362 (2013.01); B01D 15/363 (2013.01); B01D 15/3809 (2013.01); B01D 61/16 (2013.01); C07K 1/14 (2013.01); C07K 1/18 (2013.01); C07K 1/34 (2013.01); C07K 16/18 (2013.01); C07K 16/3084 (2013.01); B01D 2315/16 (2013.01); C07K 2317/14 (2013.01); C07K 2317/24 (2013.01); C07K 2317/73 (2013.01); C07K 2317/76 (2013.01);
Abstract

Disclosed here includes a method for purifying a biologic composition, comprising diafiltering the biologic composition into a composition comprising phosphate buffered saline (PBS) to obtain a purified composition. The method disclosed here can be particularly useful for removing one or more impurities from the biologic composition, such as bis(2-hydroxyethyl)amino-tris(hydroxymethyl)methane (Bis-tris).


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