The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 15, 2025
Filed:
Aug. 09, 2018
Acea Therapeutics, Inc., San Diego, CA (US);
Hangzhou Acea Pharmaceutical Research Co., Ltd, Hangzhou, CN;
Zhejiang Acea Pharmaceuticals Co., Ltd., Quzhou, CN;
Long Mao, San Diego, CA (US);
Jia Liu, San Diego, CA (US);
Yile Chen, Hangzhou, CN;
Yuning Hua, Hangzhou, CN;
Kunhua Dong, Hangzhou, CN;
Liang Chen, Hangzhou, CN;
Bojie Weng, Hangzhou, CN;
Xiaopeng Mo, Hangzhou, CN;
Kongen Dai, Hangzhou, CN;
Yimei Bao, Hangzhou, CN;
Jian Wu, Hangzhou, CN;
Bin Liang, Hangzhou, CN;
Guanglin Zhou, Hangzhou, CN;
Zhen Wang, Hangzhou, CN;
ACEA Therapeutics, Inc., San Diego, CA (US);
Abstract
The invention relates to solid forms of certain N-(pyrimidinyloxy)acrylamide derivatives that are useful in the treatment of proliferation and immunological disorders and other diseases related to the dysregulation of kinases including EGFR (including HER), Alk, PDGFR, BLK, BMX/ETK, BTK, FLT3 (D835Y), ITK, JAK1, JAK2, JAK3, TEC and TXK. The invention provides methods of making these materials and their salts and polymorphs, and intermediates for preparing these materials, as well as pharmaceutical compositions comprising these materials. The solid forms and pharmaceutical compositions comprising them are useful to treat conditions including a proliferation disorder, a tumor, an inflammatory disease, an autoimmune disease, psoriasis, dry eye, rheumatoid arthritis, or lupus.