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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12358866 B1

PDFFull Text
Date of Patent:
Jul. 15, 2025

Filed:

Feb. 06, 2024

Antioxidant inflammation modulators: oleanolic acid derivatives with amino and other modifications at c-17

Applicant:

Reata Pharmaceuticals Holdings, Llc, Plano, TX (US);

Inventors:

Eric Anderson, Southlake, TX (US);

Xin Jiang, Coppell, TX (US);

Melean Visnick, Irving, TX (US);

Assignee:

REATA PHARMACEUTICALS HOLDINGS, LLC, Plano, TX (US);

Attorney:

Parker Highlander PLLC

Primary Examiner:

Alicia L Otton

Int. Cl.
CPC ...
C07C 255/47 (2006.01); C07C 271/24 (2006.01); C07C 275/26 (2006.01); C07C 275/34 (2006.01); C07C 311/07 (2006.01); C07C 311/09 (2006.01); C07C 311/10 (2006.01); C07D 209/56 (2006.01); C07D 211/44 (2006.01); C07D 231/12 (2006.01); C07D 261/08 (2006.01); C07D 261/20 (2006.01); C07D 295/195 (2006.01); C07D 295/215 (2006.01); C07D 307/20 (2006.01); C07D 333/34 (2006.01); C07D 487/08 (2006.01); C07J 63/00 (2006.01);
U.S. Cl.
CPC ...
C07C 255/47 (2013.01); C07C 271/24 (2013.01); C07C 275/26 (2013.01); C07C 275/34 (2013.01); C07C 311/07 (2013.01); C07C 311/09 (2013.01); C07C 311/10 (2013.01); C07D 209/56 (2013.01); C07D 211/44 (2013.01); C07D 231/12 (2013.01); C07D 261/08 (2013.01); C07D 261/20 (2013.01); C07D 295/195 (2013.01); C07D 295/215 (2013.01); C07D 307/20 (2013.01); C07D 333/34 (2013.01); C07D 487/08 (2013.01); C07J 63/008 (2013.01); C07C 2603/52 (2017.05);
Abstract

This invention provides, but is not limited to, novel oleanolic acid derivatives having the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.

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