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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12358863 B1

PDFFull Text
Date of Patent:
Jul. 15, 2025

Filed:

Oct. 16, 2020

Nitrogen-containing derivative of substituted phenol hydroxy acid ester, and preparation and use thereof

Applicant:

West China Hospital, Sichuan University, Sichuan, CN;

Inventors:

Jun Yang, Sichuan, CN;

Jin Liu, Sichuan, CN;

Weiyi Zhang, Sichuan, CN;

Assignee:

WEST CHINA HOSPITAL, SICHUAN UNIVERSITY, Sichuan, CN;

Attorneys:

NKL Law

Allen Xue

Primary Examiner:

Joseph K McKane

Assistant Examiner:

Sagar Patel

Int. Cl.
CPC ...
C07C 229/08 (2006.01); A61K 31/198 (2006.01); A61K 31/215 (2006.01); A61K 31/445 (2006.01); A61K 31/5375 (2006.01); A61P 23/00 (2006.01); A61P 25/00 (2006.01); C07C 53/18 (2006.01); C07C 69/01 (2006.01); C07C 229/12 (2006.01); C07C 237/06 (2006.01); C07C 309/04 (2006.01); C07C 309/29 (2006.01); C07C 309/30 (2006.01); C07C 323/58 (2006.01); C07D 205/02 (2006.01); C07D 205/04 (2006.01); C07D 207/00 (2006.01); C07D 207/16 (2006.01); C07D 211/00 (2006.01); C07D 211/60 (2006.01); C07D 265/28 (2006.01); C07D 265/30 (2006.01); C07D 295/15 (2006.01);
U.S. Cl.
CPC ...
C07C 229/08 (2013.01); A61P 23/00 (2018.01); C07C 229/12 (2013.01); C07C 237/06 (2013.01); C07C 323/58 (2013.01); C07D 205/04 (2013.01); C07D 207/16 (2013.01); C07D 211/60 (2013.01); C07D 265/30 (2013.01); C07D 295/15 (2013.01);
Abstract

A nitrogen-containing derivative of substituted phenol hydroxyl acid ester is represented by formula (I). A salt of the compound of formula (I) has good water solubility, and in vivo, can rapidly and completely release substituted phenols having a pharmacological effect, which can improve the water solubility of substituted phenols, rapidly exert the pharmacological effects of substituted phenols in vivo, and has good safety. The method for preparing the above-mentioned compound is provided. This compound can also be used in the preparation of drugs that produce anaesthesia and/or sedative and hypnotic effects on humans and animals.

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