The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 15, 2025
Filed:
Jun. 21, 2024
Applicant:
Suzhou Nggt Biotechnology Co., Ltd., Suzhou, CN;
Inventors:
Assignee:
SUZHOU NGGT BIOTECHNOLOGY CO., LTD., Suzhou, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/70 (2006.01); A61K 48/00 (2006.01); A61P 27/02 (2006.01); C12N 9/02 (2006.01); C12N 15/00 (2006.01); C12N 15/63 (2006.01); C12N 15/86 (2006.01); A01K 67/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 48/005 (2013.01); A61P 27/02 (2018.01); C12N 9/0071 (2013.01); C12N 15/86 (2013.01); A61K 38/00 (2013.01); C12N 2740/15043 (2013.01); C12N 2740/16043 (2013.01); C12N 2750/14143 (2013.01); C12N 2770/32044 (2013.01); C12N 2820/60 (2013.01); C12N 2830/003 (2013.01); C12N 2830/48 (2013.01); C12N 2830/50 (2013.01); C12Y 114/14001 (2013.01);
Abstract
Provided are an optimized CPY4V2 gene and an application thereof. The gene relates to a polynucleotide for coding a CYP4V2 protein, and comprises a nucleotide sequence having 90% or over 90% of identity with a nucleotide sequence as shown in SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8 or SEQ ID NO: 9. Also provided is an expression vector comprising the gene. The expression vector can realize lasting and stable expression in retinal pigment epithelium of eyes, can effectively reduce the dosage and possible side effects of a gene therapy drug for treating BCD, and improves the therapeutic effect.