The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 15, 2025
Filed:
Mar. 07, 2025
Shandong Normal University, Jinan, CN;
Jun Zhou, Jinan, CN;
Songbo Xie, Jinan, CN;
SHANDONG NORMAL UNIVERSITY, Jinan, CN;
Abstract
The present invention belongs to the technical field of proteolysis-targeting chimera preparation and biomedical technology, and specifically relates to a FUS proteolysis-targeting chimera, preparation method and applications thereof. Specifically, the present invention designed ligands specifically binding to FUS based on the 'GGUG' RNA motif that specifically binds to FUS, and developed FUS proteolysis-targeting chimeras that specifically degrade wild-type and mutant FUS by connecting CRBN ligands at their 5' end. Meanwhile, to ensure effective action of FUS proteolysis-targeting chimeras in the brain, the present invention designed DNA nanoflowers based on transferrin receptor aptamers, which can effectively load FUS proteolysis-targeting chimeras and deliver them to the brain for action, achieving precise medicine for ALS patients with FUS mutations.