The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 15, 2025
Filed:
Dec. 23, 2021
Applicant:
The Johns Hopkins University, Baltimore, MD (US);
Inventors:
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/475 (2006.01); A61K 38/17 (2006.01); A61K 38/18 (2006.01); A61K 38/19 (2006.01); A61K 38/38 (2006.01); A61N 5/00 (2006.01); A61P 35/00 (2006.01); C07K 14/52 (2006.01); C07K 14/765 (2006.01); C07K 16/28 (2006.01); C07K 19/00 (2006.01); C12N 15/62 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1793 (2013.01); A61K 38/18 (2013.01); A61K 38/19 (2013.01); A61K 38/38 (2013.01); A61N 5/00 (2013.01); A61P 35/00 (2018.01); C07K 14/475 (2013.01); C07K 14/52 (2013.01); C07K 14/765 (2013.01); C07K 16/2827 (2013.01); C07K 19/00 (2013.01); C12N 15/62 (2013.01); A61K 45/06 (2013.01); C07K 2319/31 (2013.01);
Abstract
The present invention provides a novel fusion protein of Flt3L and albumin and its use to increase the Flt3L half-life in vivo and to deliver Flt3L to immune cells in a subject to enhance alternative dendritic cell populations. Use of the fusion protein in combination with other chemotherapeutic, radiotherapeutic and immunotherapeutic methods are also provided.