The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 15, 2025
Filed:
Sep. 22, 2023
Applicant:
Nucana Plc, Central Scotland, GB;
Inventors:
Gordon Kennovin, Central Scotland, GB;
Hugh Griffith, Central Scotland, GB;
Assignee:
NuCana plc, Edinburgh, GB;
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/7076 (2006.01); A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 31/7072 (2006.01); A61K 47/18 (2017.01); A61K 47/20 (2006.01); A61K 47/22 (2006.01); A61P 35/02 (2006.01);
U.S. Cl.
CPC ...
A61K 31/7076 (2013.01); A61K 9/0019 (2013.01); A61K 9/08 (2013.01); A61K 31/7072 (2013.01); A61K 47/18 (2013.01); A61K 47/20 (2013.01); A61K 47/22 (2013.01); A61P 35/02 (2018.01);
Abstract
This invention relates to pharmaceutical formulations and formulation strategies of protides (phosphoramidate derivatives of nucleosides) and, in particular, protides useful in the treatment of cancer such as NUC-3373 (5-fluoro-2'-deoxyuridine-5′-O-[1-naphthyl (benzoxy-L-alaninyl)] phosphate) and NUC-7738 (3′-deoxyadenosine-5′-O-[phenyl(benzyloxy-L-alaninyl)] phosphate). In particular, the invention relates to formulations which comprise a polar aprotic solvent, for example dimethyl acetamide (DMA).