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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12357580 B1

PDFFull Text
Date of Patent:
Jul. 15, 2025

Filed:

Jun. 14, 2024

Lipid nanoparticle compositions for delivery of mrna and long nucleic acids

Applicant:

The Board of Regents of the University of Texas System, Austin, TX (US);

Inventors:

Daniel J. Siegwart, Dallas, TX (US);

Qiang Cheng, Dallas, TX (US);

Assignee:

The Board of Regents of The University of Texas System, Austin, TX (US);

Attorney:

Parker Highlander PLLC

Primary Examiner:

Amy Rose Hudson

Int. Cl.
CPC ...
C07H 21/02 (2006.01); A61K 9/51 (2006.01); A61K 48/00 (2006.01); C12N 9/22 (2006.01); C12N 15/11 (2006.01); C12N 15/113 (2010.01); C12N 15/88 (2006.01);
U.S. Cl.
CPC ...
A61K 9/5123 (2013.01); A61K 48/0033 (2013.01); C12N 9/22 (2013.01); C12N 15/11 (2013.01); C12N 15/111 (2013.01); C12N 15/113 (2013.01); C12N 15/88 (2013.01); C12N 2310/11 (2013.01); C12N 2310/14 (2013.01); C12N 2310/20 (2017.05); C12N 2320/32 (2013.01);
Abstract

In some aspects, the present disclosure provides compositions of lipid nanoparticles useful for the delivery of large RNAs including mRNAs. These compositions may include a cationic ionizable lipid, a phospholipid, a PEGylated lipid, and a steroid including using less of a cationic ionizable lipid than compositions with shorter nucleic acids. These compositions may be used to treat a disease or disorder for which the delivery of an mRNA is therapeutically effective.

Find Patent Forward Citations

Siegwart, Daniel. (2025). Lipid nanoparticle compositions for delivery of mrna and long nucleic acids (U.S. Patent No. 12357580). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12357580

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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