The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 08, 2025
Filed:
Jun. 13, 2019
Avalis Medical, Inc., Menlo Park, CA (US);
Meike Herget, Woodside, CA (US);
Oren S. Knopfmacher, San Francisco, CA (US);
Michael D. Laufer, Menlo Park, CA (US);
Avails Medical, Inc., Menlo Park, CA (US);
Abstract
Various devices, systems and methods for detecting the presence of β-lactam antibiotic hydrolyzing bacteria in a sample are disclosed. In one embodiment, a method of detecting the presence of β-lactam antibiotic hydrolyzing bacteria includes introducing the sample to a filter configured to capture bacteria in the sample; introducing a buffer solution to the bacteria captured on the filter surface, wherein the buffer solution comprises a β-lactamase substrate, a β-lactamase activator, and a lysing agent to lyse cells of the bacteria to release β-lactam antibiotic hydrolyzing enzymes; exposing a sensor having an electrical characteristic to a reaction mixture comprising the buffer solution and the β-lactam antibiotic hydrolyzing enzymes; and monitoring a change in the electrical characteristic of the sensor to detect the presence of the β-lactam antibiotic hydrolyzing bacteria in the sample originally introduced.