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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12351847 B1

PDFFull Text
Date of Patent:
Jul. 08, 2025

Filed:

Oct. 02, 2020

Methods for the improved formation of acarbose

Applicant:

Bayer Aktiengesellschaft, Leverkusen, DE;

Inventors:

Alfred Puhler, Bielefeld, DE;

Jorn Kalinowski, Bielefeld, DE;

Susanne Schneiker-Bekel, Halle, DE;

Marcus Persicke, Bielefeld, DE;

Lena Schaffert, Cologne, DE;

Assignee:

UNIVERSITÄT BIELEFELD, BIELEFELD, DE;

Attorneys:

BAYER HEALTHCARE LLC

JAMES DILMORE

FERNANDO SANTOS

JONATHAN HARRIS

ANN H INGLETT

Primary Examiner:

Adam Weidner

Assistant Examiner:

Dennis Ignatius Armato, Jr

Int. Cl.
CPC ...
C12P 19/26 (2006.01); C12N 9/12 (2006.01); C12N 9/88 (2006.01); C12N 15/52 (2006.01); C12N 15/76 (2006.01); C12R 1/045 (2006.01);
U.S. Cl.
CPC ...
C12P 19/26 (2013.01); C12N 9/1241 (2013.01); C12N 9/88 (2013.01); C12N 15/52 (2013.01); C12N 15/76 (2013.01); C12R 2001/045 (2021.05); C12Y 207/07009 (2013.01); C12Y 402/01046 (2013.01);
Abstract

The present invention relates to Actinomycetales strains for the improved formation of acarbose. Provided are Actinomycetales strains which are engineered to overexpress dTDP-D-glucose-4,6-dehydratase (AcbB) and/or uridyltransferase (GtaB). Also provided are Actinomycetales strains which are engineered to have a reduced or absent expression of the small carbohydrate binding protein (Cgt) and/or a reduced or absent expression of genes which are essential for carotenoid synthesis. Also provided are tools, methods and means to generate these strains.

Find Patent Forward Citations

Puhler, Alfred. (2025). Methods for the improved formation of acarbose (U.S. Patent No. 12351847). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12351847

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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