The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 08, 2025
Filed:
May. 16, 2018
Applicant:
Georgia State University Research Foundation, Inc., Atlanta, GA (US);
Inventor:
Ming Luo, Atlanta, GA (US);
Assignee:
Georgia State University Research Foundation, Inc., Atlanta, GA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/385 (2006.01); A61K 35/766 (2015.01); C07K 14/47 (2006.01); C12N 7/00 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); A61K 35/766 (2013.01); C07K 14/4702 (2013.01); C12N 7/00 (2013.01); C12N 2310/141 (2013.01); C12N 2760/20021 (2013.01); C12N 2760/20032 (2013.01); C12N 2760/20043 (2013.01);
Abstract
Recombinant viral vectors are disclosed that contain a nucleic acid encoding a Second Mitochondria-derived Activator of Caspases (Smac) protein inserted within an RNA virus genome, wherein the Smac protein specifically binds to at least a portion of an Inhibitor of Apoptosis Protein (IAP). Also disclosed are methods of treating cancer using the disclosed vectors.