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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12351650 B1

PDFFull Text
Date of Patent:
Jul. 08, 2025

Filed:

Jun. 26, 2024

Antibodies binding to fibroblast activation protein alpha and death receptor 4

Applicant:

Genmab A/s, Valby, DK;

Inventors:

Bart E.c.g. De Goeij, Maarssen, NL;

Ilse Jongerius, De Bilt, NL;

Grietje Andringa, Utrecht, NL;

Madelon Paauwe, The Hague, NL;

Theodorus Sjouke Plantinga, Duiven, NL;

David Satijn, Nieuwegein, NL;

Jamila Laoukili, Zeist, NL;

Onno Wouter Kranenburg, Zeist, NL;

Marije Overdijk, Utrecht, NL;

Assignee:

GENMAB A/S, Valby, DK;

Attorneys:

Nelson Mullins Riley & Scarborough LLP

Jane E. Remillard, Esq.

Christopher L. Frank

Primary Examiner:

Lynn A Bristol

Int. Cl.
CPC ...
A61P 35/04 (2006.01); C07K 16/46 (2006.01); G01N 33/68 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/468 (2013.01); A61P 35/04 (2018.01); G01N 33/6854 (2013.01); A61K 2039/505 (2013.01); C07K 2317/31 (2013.01); C07K 2317/524 (2013.01); C07K 2317/526 (2013.01); C07K 2317/53 (2013.01); C07K 2317/565 (2013.01); G01N 2800/32 (2013.01);
Abstract

The present invention relates to a multispecific antibody comprising at least a FAPα binding region comprising a first heavy chain variable region and a first light chain variable region; and a DR4 binding region comprising a second heavy chain variable region and a second light chain variable region. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.

Find Patent Forward Citations

De Goeij, Bart E.c.g.. (2025). Antibodies binding to fibroblast activation protein alpha and death receptor 4 (U.S. Patent No. 12351650). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12351650

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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