The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 08, 2025
Filed:
Oct. 13, 2021
Applicant:
The Regents of the University of California, Oakland, CA (US);
Inventors:
Sotirios Tsimikas, San Diego, CA (US);
Joseph Witztum, San Diego, CA (US);
Xuchu Que, San Diego, CA (US);
Assignee:
The Regents of the University of California, Oakland, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/44 (2006.01); A61P 1/16 (2006.01); A61P 9/10 (2006.01); G01N 33/53 (2006.01);
U.S. Cl.
CPC ...
C07K 16/44 (2013.01); A61P 1/16 (2018.01); A61P 9/10 (2018.01); G01N 33/5308 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); G01N 2800/085 (2013.01);
Abstract
The disclosure provides for single chain variable fragments to MAA-oxidized specific epitopes (OSEs). The disclosure also provides single chain variable fragments that bind to MDA-OSEs or MAA-OSEs on oxidized phospholipids and methods of use thereof, including the production of transgenic animal models and the use of the fragments as therapeutic agents.