The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 08, 2025

Filed:

Feb. 15, 2024
Applicant:

Theravance Biopharma R&d Ip, Llc, South San Francisco, CA (US);

Inventors:

Adam D. Hughes, Half Moon Bay, CA (US);

Melissa Fleury, Brisbane, CA (US);

Miroslav Rapta, San Carlos, CA (US);

Venkat R. Thalladi, Foster City, CA (US);

R. Michael Baldwin, San Mateo, CA (US);

David L. Bourdet, Millbrae, CA (US);

Assignee:

Theravance Biopharma R&D IP, LLC, South San Francisco, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 261/18 (2006.01); A61K 9/00 (2006.01); A61K 9/48 (2006.01); A61K 31/415 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 261/18 (2013.01); A61K 9/0053 (2013.01); A61K 9/4816 (2013.01); A61K 31/415 (2013.01); A61K 45/06 (2013.01); C07B 2200/13 (2013.01);
Abstract

In one aspect, the invention relates to a crystalline form of the structure: or a pharmaceutically acceptable salt thereof, having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising this crystalline form; methods of using this crystalline form and its soluble form (I); and processes for preparing soluble (I) and crystalline (I') forms.


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