The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 08, 2025

Filed:

Mar. 07, 2018
Applicant:

University of York, York, GB;

Inventors:

Simon Benedict Duckett, North Yorkshire, GB;

Wissam Iali, North Yorkshire, GB;

Maria-Alexandra Olaru, North Yorkshire, GB;

Assignee:
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 49/10 (2006.01); G01R 33/28 (2006.01); G01R 33/56 (2006.01);
U.S. Cl.
CPC ...
A61K 49/106 (2013.01); G01R 33/282 (2013.01); G01R 33/5601 (2013.01);
Abstract

There is described a method for the preparation of an aqueous magnetic resonance imaging medium, said method comprising the steps of: •(i) preparing a multiphasic solvent system comprising an aqueous component and a non-aqueous component, said solvent comprising a target substrate and a SABRE hyperpolarisation transfer catalyst; •(ii) adding Hor parahydrogen gas; •(iii) agitating the solvent system to form an emulsion thereby transferring the spin order from the hyperpolarisation transfer catalyst to the target substrate; •(v) adding a solvent phase-separation promoter; and •(vi) separating the non-aqueous component and the aqueous component wherein the aqueous component contains the hyperpolarised target substrate and provides the aqueous magnetic resonance imaging medium.


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