The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 08, 2025
Filed:
Aug. 03, 2017
Gene editing of car-t cells for the treatment of t cell malignancies with chimeric antigen receptors
Applicants:
John F. Dipersio, St. Louis, MO (US);
Matthew Cooper, St. Louis, MO (US);
Inventors:
John F. DiPersio, St. Louis, MO (US);
Matthew Cooper, St. Louis, MO (US);
Assignee:
Washington University, St. Louis, MO (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 40/31 (2025.01); A61K 40/11 (2025.01); A61K 40/22 (2025.01); A61K 40/41 (2025.01); A61K 40/42 (2025.01); A61K 48/00 (2006.01); A61P 35/02 (2006.01); A61P 37/06 (2006.01); C12N 5/0783 (2010.01); C12N 15/00 (2006.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
A61K 48/0066 (2013.01); A61K 40/11 (2025.01); A61K 40/22 (2025.01); A61K 40/31 (2025.01); A61K 40/418 (2025.01); A61K 40/421 (2025.01); A61K 40/4211 (2025.01); A61K 48/0008 (2013.01); A61K 48/0058 (2013.01); A61K 48/0091 (2013.01); A61P 35/02 (2018.01); A61P 37/06 (2018.01); C12N 5/0636 (2013.01); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); A61K 2239/48 (2023.05);
Abstract
The present disclosure provides the use of fratricide-resistant chimeric antigen receptor T (CAR-T) cells targeting antigens expressed by T cell malignancies.