The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 08, 2025
Filed:
Jul. 12, 2023
Applicant:
Defence Therapeutics Inc., Vancouver, CA;
Inventor:
Simon Beaudoin, Sherbrooke, CA;
Assignee:
DEFENCE THERAPEUTICS INC., Sherbrooke, CA;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 51/10 (2006.01); A61K 45/00 (2006.01); A61K 47/54 (2017.01); A61K 47/64 (2017.01); A61K 47/68 (2017.01); C07K 16/30 (2006.01);
U.S. Cl.
CPC ...
A61K 47/6817 (2017.08); A61K 45/00 (2013.01); A61K 47/554 (2017.08); A61K 47/645 (2017.08); A61K 47/6851 (2017.08); A61K 51/1045 (2013.01); C07K 16/3015 (2013.01); C07K 2319/09 (2013.01);
Abstract
The present description relates to a conjugated compound an antibody covalently linked to enhancer moiety composed by a nuclear localization sequence (NLS), covalently linked to a sterol variant, such as cholic acid (ChAc) or a variant thereof. The enhancer moiety as encompassed herein is able to induce endosome escape of the compound-conjugates by direct membrane destabilization or indirectly by ROS and ceramide production which destabilize endosome-lysosome membrane. The conjugated compound can further comprise payload.