The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 08, 2025
Filed:
May. 12, 2021
Applicant:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Inventors:
Matthew J. Frigault, Philadelphia, PA (US);
Yangbing Zhao, Lumberton, NJ (US);
John Scholler, Narberth, PA (US);
Carl H. June, Merion Station, PA (US);
Assignee:
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 40/31 (2025.01); A61K 40/11 (2025.01); A61K 40/42 (2025.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01); C07K 16/18 (2006.01); C07K 16/30 (2006.01); C12N 5/0783 (2010.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
A61K 40/31 (2025.01); A61K 40/11 (2025.01); A61K 40/4202 (2025.01); A61K 40/4211 (2025.01); A61K 40/4255 (2025.01); C07K 14/7051 (2013.01); C07K 14/70521 (2013.01); C07K 16/18 (2013.01); C07K 16/30 (2013.01); C12N 5/0636 (2013.01); C12N 15/86 (2013.01); C07K 2319/33 (2013.01); C12N 2510/00 (2013.01); C12N 2740/15041 (2013.01); C12N 2840/00 (2013.01);
Abstract
The present invention provides compositions and methods for generating a genetically modified T cells comprising a chimeric antigen receptor (CAR) having an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a CD3 zeta signaling domain, wherein the T cell exhibits prolonged exponential expansion in culture that is ligand independent and independent of the addition of exogenous cytokines or feeder cells.