The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 08, 2025

Filed:

Mar. 21, 2019
Applicant:

Beijing Wellgene Company Ltd., Beijing, CN;

Inventors:

Chao Tian, Beijing, CN;

Xiaopeng Li, Beijing, CN;

Chunyang Sun, Beijing, CN;

Hua Zhou, Beijing, CN;

Jiajia Liu, Beijing, CN;

Jingshu Zhao, Beijing, CN;

Assignee:
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/763 (2015.01); A61P 35/00 (2006.01); C07K 14/535 (2006.01); C07K 14/54 (2006.01); C07K 14/55 (2006.01); C07K 16/28 (2006.01); C12N 7/00 (2006.01);
U.S. Cl.
CPC ...
A61K 35/763 (2013.01); A61P 35/00 (2018.01); C07K 14/535 (2013.01); C07K 14/5434 (2013.01); C07K 14/55 (2013.01); C07K 16/2818 (2013.01); C12N 7/00 (2013.01); C12N 2710/16632 (2013.01); C12N 2710/16643 (2013.01);
Abstract

Provided is a recombinant oncolytic virus composition, comprising a first recombinant oncolytic virus and a second recombinant oncolytic virus. Both the first and second recombinant oncolytic viruses comprise a herpes simplex virus vector and an exogenous gene, the exogenous gene is encoded from one of cytokine, a monoclonal antibody having a tumor preventative and/or treatment function, tumor antigens, prodrug invertase, tumor suppressor polypeptide, antisense RNA or small RNA, wherein the exogenous genes in the first and the second recombinant oncolytic viruses are different. Also provided is an application of the recombinant oncolytic virus composition in preparation of a medicament drug for treating tumors.


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