The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 08, 2025
Filed:
Jul. 21, 2020
Merck Sharp & Dohme Llc, Rahway, NJ (US);
The Walter and Eliza Hall Institute of Medical Research, Parkville, AU;
Msd R&d (China) Co. Ltd., Beijing, CN;
John A. McCauley, Maple Glen, PA (US);
Alan F. Cowman, Melbourne, AU;
Manuel De Lera Ruiz, Perkasie, PA (US);
Paola Favuzza, Melbourne, AU;
Zhuyan Guo, Scotch Plains, NJ (US);
Bin Hu, Shanghai, CN;
Michael J. Kelly, Iii, Paoli, PA (US);
Zhiyu Lei, Shanghai, CN;
David B. Olsen, Lansdale, PA (US);
Brad Sleebs, Bundoora, AU;
Jennifer K. Thompson, Melbourne, AU;
Tony Triglia, Melbourne, AU;
Dongmei Zhan, Shanghai, CN;
Cailing Zhang, Shanghai, CN;
Lianyun Zhao, Shanghai, CN;
MSD R&D (China) Co. Ltd., Beijing, CN;
The Walter and Eliza Hall Institute of Medical Research, Parkville, AU;
Merck Sharp & Dohme LLC, Rahway, NJ (US);
Abstract
Methods of treating malaria comprising administration of compounds of Formula (I') or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the variables are as defined herein. It also provides uses of the compounds of Formula (I), as defined herein, for inhibiting plasmepsin X, plasmepsin IX or plasmepsin X and IX activity, for treating ainfection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.