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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12349940 B1

PDFFull Text
Date of Patent:
Jul. 08, 2025

Filed:

Feb. 02, 2024

Autonomous denudation in an intelligent automated in vitro fertilization and intracytoplasmic sperm injection platform

Applicant:

Conceivable Life Sciences Inc., New York, NY (US);

Inventors:

Adolfo Flores-Saiffe Farias, Zapopan, MX;

Gerardo Mendizabal-Ruiz, Guadalajara, MX;

Jacques Cohen, New York, NY (US);

Alan Murray, Greenwich, CT (US);

Alejandro Chavez-Badiola, Mexico City, MX;

Angel Alvarez, Guadalajara, MX;

Assignee:

Conceivable Life Sciences Inc., New York, NY (US);

Attorney:

Miller Johnson

Primary Examiner:

Sj Park

Int. Cl.
CPC ...
G06K 9/00 (2022.01); A61B 17/425 (2006.01); A61B 17/43 (2006.01); A61B 34/30 (2016.01); C12M 1/00 (2006.01); C12M 1/02 (2006.01); C12M 1/22 (2006.01); C12M 1/26 (2006.01); C12M 1/36 (2006.01); C12M 3/00 (2006.01); C12N 5/073 (2010.01); G01N 33/50 (2006.01); G01N 35/00 (2006.01); G01N 35/10 (2006.01); G06T 7/20 (2017.01); G06T 7/70 (2017.01); G06V 10/82 (2022.01); G06V 20/69 (2022.01); A61B 34/32 (2016.01);
U.S. Cl.
CPC ...
A61B 17/43 (2013.01); A61B 17/425 (2013.01); A61B 34/30 (2016.02); C12M 21/06 (2013.01); C12M 23/10 (2013.01); C12M 23/48 (2013.01); C12M 23/50 (2013.01); C12M 33/04 (2013.01); C12M 41/06 (2013.01); C12M 41/18 (2013.01); C12M 41/48 (2013.01); C12N 5/0604 (2013.01); G01N 33/5091 (2013.01); G01N 35/0099 (2013.01); G01N 35/10 (2013.01); G01N 35/1011 (2013.01); G06T 7/20 (2013.01); G06T 7/70 (2017.01); G06V 10/82 (2022.01); G06V 20/693 (2022.01); A61B 34/32 (2016.02); G06T 2207/20081 (2013.01); G06T 2207/30024 (2013.01); G06V 20/69 (2022.01); G06V 20/698 (2022.01); G06V 2201/03 (2022.01);
Abstract

A method for automated, artificial-intelligence-based denudation includes scanning, robotically, a dish containing a cumulus-oocyte-complex (COC) using an imaging system and an artificial intelligence/machine learning system (AI/ML system) to create an image object. The imaging system includes a microscopy system, a camera system, and a lighting system. The dish includes an enzyme to remove cumulus cells from an oocyte among the COC. The method includes identifying the COC within the image object, and a location, based on comparing the image object to a threshold using the AI/ML system. The threshold is an optical pattern with a probability of corresponding to a COC mass. The method includes instructing a robotic pipettor to collect the COC at the location. The method includes iteratively collecting the COC within the robotic pipettor and expelling the COC to return it to the dish until the AI/ML system confirms sufficient removal of cumulus and corona cells.

Find Patent Forward Citations

Flores-Saiffe Farias, Adolfo. (2025). Autonomous denudation in an intelligent automated in vitro fertilization and intracytoplasmic sperm injection platform (U.S. Patent No. 12349940). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/12349940

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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