The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 01, 2025
Filed:
Jun. 12, 2019
Applicant:
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Inventors:
Martina Geiger, Schlieren, CH;
Christian Klein, Schlieren, CH;
Assignee:
Hoffmann-La Roche Inc., Little Falls, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/00 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); C12Q 1/6897 (2018.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
G01N 33/57484 (2013.01); C07K 16/2809 (2013.01); C07K 16/30 (2013.01); C12Q 1/6897 (2013.01); C07K 2317/31 (2013.01); C07K 2317/622 (2013.01);
Abstract
The present invention relates to a new cell-based assay for determining antigen expression in primary tumor samples. The method further relates to the determination of antigen and protease expression in primary tumor samples. The method allows robust determination of antigen and/or protease expression without the need to digest the tumor samples. The method further allows for selection of antibodies and for selection of protease-cleavable linkers for the treatment of tumors.