The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 01, 2025

Filed:

Nov. 05, 2019
Applicant:

Cellino Biotech, Inc., Cambridge, MA (US);

Inventors:

Stan Wang, Cambridge, MA (US);

Suvi Aivio, Cambridge, MA (US);

Matthias Wagner, Cambridge, MA (US);

Catherine Pilsmaker, Cambridge, MA (US);

Marinna Madrid, Cambridge, MA (US);

Assignee:

Cellino Biotech, Inc., Cambridge, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/85 (2006.01); C12N 5/00 (2006.01); C12N 5/074 (2010.01); C12N 5/079 (2010.01); C12N 9/22 (2006.01); C12N 13/00 (2006.01); C12N 15/11 (2006.01); C12N 15/87 (2006.01); C12N 15/90 (2006.01); G01N 15/1433 (2024.01); G01N 15/1434 (2024.01); G03F 7/00 (2006.01); G03F 7/20 (2006.01); G01N 15/10 (2006.01);
U.S. Cl.
CPC ...
C12N 15/85 (2013.01); C12N 5/0068 (2013.01); C12N 5/0621 (2013.01); C12N 5/0696 (2013.01); C12N 9/22 (2013.01); C12N 13/00 (2013.01); C12N 15/11 (2013.01); C12N 15/87 (2013.01); C12N 15/907 (2013.01); G01N 15/1433 (2024.01); G01N 15/1434 (2013.01); G03F 7/2006 (2013.01); G03F 7/70025 (2013.01); G03F 7/7055 (2013.01); C12N 2310/20 (2017.05); C12N 2506/08 (2013.01); C12N 2506/45 (2013.01); C12N 2800/80 (2013.01); G01N 2015/1006 (2013.01);
Abstract

The disclosure relates to growing cells, directing cells to grow into specified cell types, genetically and physically manipulating cells, and addressing one or more individual cells within a mixed cell population. Aspects of the disclosure relate to vectors useful to induce developmental changes in cells, in which those vectors have a temporal component. Vectors of the disclosure encode a controllable, temporal series of events. Once the vectors are delivered into target cells, a series of discrete and different genetic events may be induced. The disclosed methods generally provide for the temporal encoding of multiplex genetic effectors in vector format for cell state transitions.


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