The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 01, 2025
Filed:
Aug. 22, 2022
Applicant:
University of Massachusetts, Boston, MA (US);
Inventors:
Sankaran Thayumanavan, Amherst, MA (US);
Kingshuk Dutta, Amherst, MA (US);
Assignee:
University of Massachusetts, Westborough, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C08F 299/04 (2006.01); A61K 47/54 (2017.01); A61K 47/58 (2017.01); C08F 220/38 (2006.01); B82Y 5/00 (2011.01);
U.S. Cl.
CPC ...
C08F 299/04 (2013.01); A61K 47/543 (2017.08); A61K 47/58 (2017.08); C08F 220/385 (2020.02); B82Y 5/00 (2013.01);
Abstract
The invention provides novel polymers, crosslinked polymer-nucleic acid complexes, lipid-polymer-nucleic acid-based complexation and nanoassemblies, and nanoassembly-based intracellular delivery of nucleic acids and controlled release thereof upon degradation of the nanoassemblies in response to specific microenvironment in the cell, and compositions and methods of preparation and use thereof.