The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 01, 2025
Filed:
Nov. 29, 2017
Applicant:
Xlifesc, Ltd., Guangdong, CN;
Inventors:
Yi Li, Guangdong, CN;
Jinhua Huang, Guangdong, CN;
Assignee:
XLIFESC, LTD., Guangdong, CN;
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/725 (2006.01); C07K 16/28 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/7051 (2013.01); C07K 16/2809 (2013.01); A61K 38/00 (2013.01); C07K 2317/622 (2013.01); C07K 2319/30 (2013.01);
Abstract
Provided is a T cell receptor (TCR) having a property of binding to a SLLMWITQC (SEQ ID NO: 105)-HLA A2 complex; and the binding affinity of the TCR to the SLLMWITQC (SEQ ID NO: 105)-HLA A2 complex is at least twice that of a wild-type TCR to the SLLMWITQC (SEQ ID NO: 105)-HLA A2 complex. Also provided is a fusion molecule of such a TCR with a therapeutic agent. Such a TCR can be used alone or in combination with a therapeutic agent so as to target tumour cells presenting the SLLMWITQC (SEQ ID NO: 105)-HLA A2 complex.