The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 01, 2025

Filed:

Nov. 08, 2022
Applicant:

Genexine, Inc., Seongnam-si, KR;

Inventors:

Donghoon Choi, Seongnam-si, KR;

Changyong Eun, Seoul, KR;

Seong Hoon Jeong, Goyang-si, KR;

Jun Yeul Lim, Busan, KR;

Assignee:

Genexine, Inc., Seongnam-si, KR;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/54 (2006.01); A61K 9/08 (2006.01); A61K 38/20 (2006.01); A61K 47/10 (2017.01); A61K 47/12 (2006.01); A61K 47/18 (2017.01); A61K 47/26 (2006.01); C07K 5/062 (2006.01); C07K 5/083 (2006.01); C07K 5/103 (2006.01); C07K 7/06 (2006.01);
U.S. Cl.
CPC ...
C07K 14/5418 (2013.01); A61K 9/08 (2013.01); A61K 38/2046 (2013.01); A61K 47/10 (2013.01); A61K 47/12 (2013.01); A61K 47/183 (2013.01); A61K 47/26 (2013.01); C07K 7/06 (2013.01); C07K 14/54 (2013.01); C07K 5/06026 (2013.01); C07K 5/0606 (2013.01); C07K 5/0806 (2013.01); C07K 5/081 (2013.01); C07K 5/1008 (2013.01); C07K 5/1013 (2013.01); C07K 2319/30 (2013.01);
Abstract

Provided is a pharmaceutical formulation comprising a modified IL-7 protein. More particularly, it comprises (a) a modified IL-7 fusion protein; (b) a basal buffer with a concentration of 10 to 50 mM; (c) a sugar with a concentration of 2.5 to 5 w/v %; and (d) a surfactant with a concentration of 0.05 to 6 w/v %. Such pharmaceutical formulation of a modified IL-7 fusion protein does not show aggregates formation, but shows protective effects on proteins under stress conditions such as oxidation or agitation, and thus can effectively be used for the treatment of a patient.


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