The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 01, 2025
Filed:
Dec. 07, 2017
Applicants:
The University of Chicago, Chicago, IL (US);
Dana-farber Cancer Institute, Inc., Boston, MA (US);
Inventors:
James LaBelle, Chicago, IL (US);
Rachel Eclov, Chicago, IL (US);
Gregory Bird, Boston, MA (US);
Loren D. Walensky, Boston, MA (US);
Assignees:
The University of Chicago, Chicago, IL (US);
Dana-Farber Cancer Institute, Inc., Boston, MA (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/47 (2006.01); A61K 38/00 (2006.01); C07K 1/107 (2006.01); C07K 14/73 (2006.01);
U.S. Cl.
CPC ...
C07K 14/4713 (2013.01); C07K 1/1077 (2013.01); C07K 14/70514 (2013.01); A61K 38/00 (2013.01);
Abstract
Provided herein are peptide-based therapeutics that target FOXP3 and methods of use thereof to decrease the immuno-suppressive effects of Tregs and inhibit immune dysregulation, while sparring inhibition of activated cytotoxic T cells, for example, in the context of anti-tumor immune responses, autoimmunity, inflammatory conditions, etc.