The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 01, 2025
Filed:
May. 26, 2021
Applicant:
Nanophagix Llc, Berwyn, PA (US);
Inventors:
Steven Jay Adelman, Doylestown, PA (US);
H. Donlon Skerrett, Wayne, PA (US);
William A. Kinney, Newtown, PA (US);
Assignee:
NANOPHAGIX, Berwyn, PA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 491/153 (2006.01); A61K 47/54 (2017.01); A61P 1/00 (2006.01); A61P 9/10 (2006.01); A61P 19/02 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); C07D 491/18 (2006.01);
U.S. Cl.
CPC ...
C07D 491/153 (2013.01); A61K 47/542 (2017.08); A61P 1/00 (2018.01); A61P 9/10 (2018.01); A61P 19/02 (2018.01); A61P 29/00 (2018.01); A61P 35/00 (2018.01); C07D 491/18 (2013.01);
Abstract
The present invention relates to compounds, and methods of use thereof, capable of entering macrophages. The invention further relates to compounds capable of modulating (for example inhibiting) the activity of the mammalian target of rapamycin (mTor), treating mTor-associated diseases, in particular, but not limited to, related to mTor in macrophages. The invention also relates to compounds capable of imaging mTor in a subject, in particular, but not limited to, mTor in macrophages.