IDiyas

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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12344595 B1

PDFFull Text
Date of Patent:
Jul. 01, 2025

Filed:

Oct. 28, 2019

2-amino-n-phenyl-nicotinamides as nav1.8 inhibitors

Applicant:

Merck Sharp & Dohme Llc, Rahway, NJ (US);

Inventors:

Michael J. Breslin, Drexel Hill, PA (US);

Christopher James Bungard, Lansdale, PA (US);

Harry R. Chobanian, Westfield, NJ (US);

Kristen L. G. Jones, Oreland, PA (US);

Mark E. Layton, Harleysville, PA (US);

Jian Liu, Edison, NJ (US);

James J. Perkins, Churchville, PA (US);

Jeffrey William Schubert, North Wales, PA (US);

Shawn J. Stachel, Perkasie, PA (US);

Linda M. Suen-Lai, Philadelphia, PA (US);

Zhe Wu, Blue Bell, PA (US);

Assignee:

Merck Sharp & Dohme LLC, Rahway, NJ (US);

Attorneys:

Baerbel R. Brown

Catherine D. Fitch

Primary Examiner:

Joseph K McKane

Assistant Examiner:

Quincy McKoy

Int. Cl.
CPC ...
C07D 401/04 (2006.01); C07D 213/82 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 413/04 (2006.01); C07D 417/04 (2006.01); C07D 417/14 (2006.01); C07D 451/02 (2006.01); C07D 487/08 (2006.01); C07D 487/18 (2006.01); C07D 491/048 (2006.01); C07D 491/107 (2006.01); C07D 498/04 (2006.01); C07D 498/08 (2006.01); C07D 513/04 (2006.01);
U.S. Cl.
CPC ...
C07D 401/04 (2013.01); C07D 213/82 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 413/04 (2013.01); C07D 417/04 (2013.01); C07D 417/14 (2013.01); C07D 451/02 (2013.01); C07D 487/08 (2013.01); C07D 487/18 (2013.01); C07D 491/048 (2013.01); C07D 491/107 (2013.01); C07D 498/04 (2013.01); C07D 498/08 (2013.01); C07D 513/04 (2013.01);
Abstract

Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are inhibitors of Na1.8 channel activity and may be useful in the treatment, prevention, management, amelioration, control and suppression of diseases mediated by Na1.8 channel activity. The compounds of the present invention may be useful in the treatment, prevention or management of pain disorders, cough disorders, acute itch disorders, and chronic itch disorders.

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