The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 01, 2025
Filed:
May. 16, 2019
Applicant:
Regents of the University of Minnesota, Minneapolis, MN (US);
Inventors:
Mark J. Osborn, St. Louis Park, MN (US);
Keli Hippen, Minneapolis, MN (US);
Bruce R. Blazer, Minneapolis, MN (US);
Assignee:
Regents of the University of Minnesota, Minneapolis, MN (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61P 37/06 (2006.01); A61K 31/436 (2006.01); A61K 31/573 (2006.01); A61K 35/28 (2015.01); A61K 38/13 (2006.01); A61K 40/10 (2025.01); A61K 40/11 (2025.01); A61K 40/22 (2025.01); A61K 40/41 (2025.01); A61K 45/06 (2006.01); C07K 14/705 (2006.01); C12N 5/0783 (2010.01); C12N 9/16 (2006.01); C12N 9/22 (2006.01); C12N 15/11 (2006.01); C12N 15/90 (2006.01);
U.S. Cl.
CPC ...
A61K 45/06 (2013.01); A61K 31/436 (2013.01); A61K 31/573 (2013.01); A61K 35/28 (2013.01); A61K 38/13 (2013.01); A61K 40/10 (2025.01); A61K 40/11 (2025.01); A61K 40/22 (2025.01); A61K 40/418 (2025.01); A61P 37/06 (2018.01); C07K 14/705 (2013.01); C12N 5/0637 (2013.01); C12N 9/16 (2013.01); C12N 9/22 (2013.01); C12N 15/11 (2013.01); C12N 15/907 (2013.01); C12Y 301/03016 (2013.01); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); C12N 2310/20 (2017.05); C12N 2800/80 (2013.01);
Abstract
The present disclosure provides modified cells including pluripotent stem cells, hematopoietic precursor cells, and hematopoietic cells (e.g., modified Tregs) that are steroid and/or calcineurin inhibitor-resistant. The present disclosure provides methods for generating steroid and/or calcineurin inhibitor-resistant modified cells including pluripotent stem cells, hematopoietic precursor cells, and hematopoietic cells. Also provided herein are compositions and methods of treatment.