The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 01, 2025
Filed:
May. 08, 2020
Applicant:
The Board of Regents of the University of Oklahoma, Norman, OK (US);
Inventors:
Jimmy D. Ballard, Norman, OK (US);
Sarah J. Bland, Oklahoma City, OK (US);
Assignee:
The Board of Regents of the University of Oklahoma, Norman, OK (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/08 (2006.01); A61K 39/00 (2006.01); A61K 47/02 (2006.01); C12N 15/10 (2006.01); C12N 15/63 (2006.01);
U.S. Cl.
CPC ...
A61K 39/08 (2013.01); A61K 47/02 (2013.01); C12N 15/102 (2013.01); C12N 15/63 (2013.01); A61K 2039/52 (2013.01); A61K 2039/55544 (2013.01);
Abstract
An immunogenic composition comprising a deletion mutant of aTcdB toxin (such as TcdB2 or TcdB1) that lacks residues at least from amino acid residue 1769 to amino acid residue 1787 of a wild-type TcdB amino acid sequence or of a protein having high identity thereto, a vaccine comprising the immunogenic composition, a method of stimulating an immune response, a nucleic acid which encodes the amino acid sequence of the deletion mutant, a vector encoding the nucleic acid, and a host cell comprising the vector.