IDiyas

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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12343343 B1

PDFFull Text
Date of Patent:
Jul. 01, 2025

Filed:

Apr. 30, 2024

Five-membered ring-fused six-membered ring compound, preparation method therefor, and pharmaceutical composition and use thereof

Applicant:

Hangzhou Polymed Biopharmaceuticals, Inc., Zhejiang, CN;

Inventors:

Jason Shaoyun Xiang, Hangzhou, CN;

Lei Wu, Hangzhou, CN;

Bing Zhang, Hangzhou, CN;

Qiang Zhang, Hangzhou, CN;

Gang Yang, Hangzhou, CN;

Rui Xu, Hangzhou, CN;

Shuai Yang, Hangzhou, CN;

Yue Wu, Hangzhou, CN;

Suyue Wang, Hangzhou, CN;

Rui Yang, Hangzhou, CN;

Assignee:

Hangzhou Polymed Biopharmaceuticals, Inc., Hangzhou, CN;

Attorney:

Proskauer Rose LLP

Primary Examiner:

Clinton A Brooks

Assistant Examiner:

Josmalen M Ramos-Lewis

Int. Cl.
CPC ...
A61K 31/496 (2006.01); A61K 31/4545 (2006.01); A61K 31/519 (2006.01); A61K 31/5377 (2006.01); A61K 31/5386 (2006.01); C07D 401/14 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 487/04 (2006.01); C07D 498/08 (2006.01); C07D 519/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/496 (2013.01); A61K 31/4545 (2013.01); A61K 31/519 (2013.01); A61K 31/5377 (2013.01); A61K 31/5386 (2013.01); C07D 401/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 487/04 (2013.01); C07D 498/08 (2013.01); C07D 519/00 (2013.01);
Abstract

Disclosed in the present invention are a five-membered ring-fused six-membered ring compound, a preparation method therefor, and a pharmaceutical composition and the use thereof. Provided in the present invention is a compound as represented by formula (I), or a pharmaceutically acceptable salt or an isotope compound thereof. The compound of the present invention has an inhibition and/or degradation effect on IRAK4.

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