The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 24, 2025
Filed:
Jun. 11, 2024
The Children's Medical Center Corporation, Boston, MA (US);
The United States of America, As Represented BY the Secretary, Department of Health & Human Services, Bethesda, MD (US);
Anjana Rao, La Jolla, CA (US);
Mamta Tahiliani, New York, NY (US);
Kian Peng Koh, Jamaica Plain, MA (US);
Suneet Agarwal, Belmont, MA (US);
Aravind Iyer, Bethesda, MD (US);
Abstract
The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.