The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 24, 2025

Filed:

Oct. 24, 2023
Applicant:

Battelle Memorial Institute, Richland, WA (US);

Inventors:

Shuang Deng, Richland, WA (US);

Jon K. Magnuson, Richland, WA (US);

Joonhoon Kim, Berkeley, CA (US);

Kyle R. Pomraning, Richland, WA (US);

Ziyu Dai, Richland, WA (US);

Beth A. Hofstad, Richland, WA (US);

Assignee:

Battelle Memorial Institute, Richland, WA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P 7/46 (2006.01); C12N 1/14 (2006.01); C12R 1/69 (2006.01);
U.S. Cl.
CPC ...
C12P 7/46 (2013.01); C12N 1/145 (2021.05); C12R 2001/69 (2021.05);
Abstract

Recombinantgenetically modified to increase expression of g8846, renamed herein as aconitic acid exporter (aexA), are provided, which in some examples are also genetically inactivated for an endogenous cis-aconitic acid decarboxylase (cadA) gene. Such recombinantproduce more aconitic acid as compared to native. Also provided are methods of using such recombinantto increase production of aconitic acid and other organic acids, such as citric acid, itaconic acid, and 3-hydroxypropionic acid (3-HP).


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