The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 24, 2025
Filed:
Nov. 16, 2017
Applicant:
Allele Biotechnology and Pharmaceuticals, Inc., San Diego, CA (US);
Inventors:
Assignee:
ALLELE BIOTECHNOLOGY AND PHARMACEUTICALS, INC., San Diego, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0678 (2013.01); C12N 5/0676 (2013.01); C12N 15/85 (2013.01); C12N 2500/25 (2013.01); C12N 2500/34 (2013.01); C12N 2500/38 (2013.01); C12N 2501/155 (2013.01); C12N 2501/16 (2013.01); C12N 2501/385 (2013.01); C12N 2501/395 (2013.01); C12N 2501/415 (2013.01); C12N 2501/60 (2013.01); C12N 2501/727 (2013.01); C12N 2501/998 (2013.01); C12N 2506/45 (2013.01); C12N 2533/54 (2013.01); C12N 2533/90 (2013.01);
Abstract
A novel method of inducing or producing pancreatic beta cells from human induced pluripotent stem cells at an unprecedented efficiency and functionality. The core of the invention is the use of experimentally discovered mRNAs at multiple critical differentiation decision points along a pluripotent to mesendoderm to endoderm to pancreatic endocrine cells to pancreatic beta cells pathway in a previously unknown manner.