The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 24, 2025
Filed:
Jul. 05, 2023
Applicant:
Alnylam Pharmaceuticals, Inc., Cambridge, MA (US);
Inventors:
Akin Akinc, Needham, MA (US);
Gregory Hinkle, Plymouth, MA (US);
Martin A. Maier, Belmont, MA (US);
James Butler, Lynnfield, MA (US);
Jingxuan Liu, West Roxbury, MA (US);
Assignee:
Alnylam Pharmaceuticals, Inc., Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); A61K 31/713 (2006.01); A61K 45/06 (2006.01); A61K 47/54 (2017.01); C07H 21/02 (2006.01); C12N 15/113 (2010.01); C12Q 1/6883 (2018.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 31/713 (2013.01); A61K 45/06 (2013.01); A61K 47/549 (2017.08); C12N 15/1137 (2013.01); C12Q 1/6883 (2013.01); C12N 2310/14 (2013.01); C12N 2310/31 (2013.01); C12N 2310/321 (2013.01); C12N 2310/322 (2013.01); C12N 2310/344 (2013.01);
Abstract
The present invention relates to RNAi agents, e.g., double stranded RNAi agents, targeting the Kallikrein B, Plasma (Fletcher Factor) 1 (KLKB1) gene, the Factor XII (Hageman Factor (F12) gene, or the Kininogen 1 (KNG1) gene, and methods of using such RNAi agents to inhibit expression of a KLKB1 gene, an F12 gene, and/or a KNG1 gene, and methods of treating subjects having an hereditary angioedema (HAE) and/or a contact activation pathway-associated disorder.