The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 24, 2025
Filed:
May. 03, 2019
Genmab B.v., Utrecht, NL;
Rob De Jong, Utrecht, NL;
Frank Beurskens, Utrecht, NL;
Simone Oostindie, Utrecht, NL;
Aran Frank Labrijn, Nigtevecht, NL;
Kristin Strumane, Werkhoven, NL;
Janine Schuurman, Diemen, NL;
Bart-Jan De Kreuk, Utrecht, NL;
GENMAB B.V., Utrecht, NL;
Abstract
Provided herein are combinations of first and second antibodies having modified Fc effector functions resulting from amino acid substitutions in the Fc region, the amino acid substitutions allow for co-dependent activation of effector functions such as CDC and/or ADCC. Also provided are combinations of first and second antibodies having agonistic activity or enhanced agonistic activity resulting from amino acid substitutions in the Fc region where the agonistic activity is co-dependent of both a first and second antibodies.