The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 24, 2025
Filed:
Jun. 06, 2019
Applicant:
Disarm Therapeutics, Inc., Cambridge, MA (US);
Inventors:
Robert Owen Hughes, Newtown, CT (US);
Rajesh Devraj, Chesterfield, MO (US);
Todd Bosanac, New Milford, CT (US);
Richard Andrew Jarjes-Pike, Newbury, GB;
Andrew Simon Brearley, Chilton, GB;
Jonathan Bentley, Abingdon, GB;
Assignee:
Disarm Therapeutics, Inc., Indianapolis, IN (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61P 25/28 (2006.01); C07D 217/02 (2006.01); C07D 217/22 (2006.01); C07D 217/24 (2006.01); C07D 237/28 (2006.01); C07D 237/30 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61P 25/28 (2018.01); C07D 217/02 (2013.01); C07D 217/22 (2013.01); C07D 217/24 (2013.01); C07D 237/28 (2013.01); C07D 237/30 (2013.01);
Abstract
The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing neurodegenerative disease or axonal degeneration. The provided SARM1 inhibitors may reduce or inhibit binding of NAD+ by SARM1. Alternatively, provided SARM1 inhibitors bind to SARM1 within a pocket comprising one or more catalytic residues (e.g., a catalytic cleft of SARM1).