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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 12338230 B1

PDFFull Text
Date of Patent:
Jun. 24, 2025

Filed:

Jan. 22, 2024

Aryl, heteroaryl, and heterocyclic compounds for treatment of immune and inflammatory disorders

Applicant:

Achillion Pharmaceuticals, Inc., Boston, MA (US);

Inventors:

Jason Allan Wiles, Madison, CT (US);

Avinash S. Phadke, Branford, CT (US);

Milind Deshpande, Madison, CT (US);

Atul Agarwal, Hamden, CT (US);

Dawei Chen, Guilford, CT (US);

Venkat Rao Gadhachanda, Hamden, CT (US);

Akihiro Hashimoto, Branford, CT (US);

Godwin Pais, Hamden, CT (US);

Qiuping Wang, Bethany, CT (US);

Xiangzhu Wang, Branford, CT (US);

William Greenlee, Teaneck, NJ (US);

Assignee:

Achillion Pharmaceuticals, Inc., Boston, MA (US);

Attorney:

Clark & Elbing LLP

Primary Examiner:

Shawquia Jackson

Int. Cl.
CPC ...
C07D 407/14 (2006.01); A61P 1/16 (2006.01); A61P 29/00 (2006.01); A61P 37/00 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 403/10 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 413/14 (2006.01); C07D 417/14 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 487/22 (2006.01); C07D 493/04 (2006.01); C07D 513/04 (2006.01); C07D 519/00 (2006.01); C07F 9/6558 (2006.01);
U.S. Cl.
CPC ...
C07D 403/04 (2013.01); A61P 1/16 (2018.01); A61P 29/00 (2018.01); A61P 37/00 (2018.01); C07D 401/14 (2013.01); C07D 403/10 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/14 (2013.01); C07D 407/14 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 487/22 (2013.01); C07D 493/04 (2013.01); C07D 513/04 (2013.01); C07D 519/00 (2013.01); C07F 9/65583 (2013.01);
Abstract

Compounds, methods of use, and processes for making inhibitors of complement Factor D are provided comprising Formula I, I″ and I'″ or a pharmaceutically acceptable salt or composition thereof. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein reduces the excessive activation of complement.

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