Long-acting antibacterial anti-stenosis functional urethral stent and preparation method thereof

Abstract

A long-acting antibacterial anti-stenosis functional urethral stent and preparation method thereof is provided; the urethral stent is a tubular structure consisting of three layers: inner, middle and outer layers; the middle layer is a fabric tube; the outer layer is a silk fibroin film carrying anti-stenosis drugs; the inner layer is an antibacterial antifouling coating, consisting of chitosan-nanosilica arrays, villi, microvilli and antibacterial drugs; the preparation method includes: after making yarns into the fabric tube by textile molding, preparing the antibacterial and anti-fouling coating on the inner surface, and the silk fibroin film carrying anti-stenosis drugs on the outer surface respectively, to obtain the long-acting antibacterial anti-stenosis functional urethral stent. The method is simple, and the prepared urethral stent has a smooth surface and good biocompatibility, which has excellent properties such as radial compression force, circumferential expansion force, resistance to bending and torsion and elastic recovery.