Apparatus and method for controlling infusion rate of pre- and post-dilution in extracorporeal blood treatment

Abstract

An apparatus () for extracorporeal blood treatment, comprising an infusion control arrangement () arranged for infusing a pre-dilution flow rate upstream a blood treatment unit () and a post-dilution flow rate downstream the blood treatment unit (), an ultrafiltration, UF, arrangement () arranged for ultrafiltration of a liquid through a semipermeable membrane () of the blood treatment unit () and a control unit (). The control unit () is configured to configure the infusion control arrangement () to obtain a plurality of different configurations of the pre-dilution flow rate and/or post-dilution flow rate. For each of the plurality of different configurations, the control unit () is configured to change an operating situation of the UF arrangement (), to detect a plurality of ultrafiltration flow rate values through the membrane () as a function of TMP, on changing said operating situation, and to evaluate an optimal ultrafiltration flow rate value from a comparison of the detected ultrafiltration flow rates. The apparatus () is also configured to estimate a clearance value for a certain solute at the optimal ultrafiltration flow rate value and to evaluate a preferred configuration of the pre-dilution flow rate and/or post-dilution flow rate from a comparison of the corresponding estimated clearance values.